abstract：:Thirty patients suffering from essential hypertension were treated successively with placebo, hydralazine alone, and pindolol (Visken) combined with hydralazine. Hydralazine caused a statistically significant reduction in blood pressure and an increase in pulse rate as compared with the placebo: palpitations were an i...

journal_title：European journal of clinical pharmacology

authors： Persson I

更新日期：1975-12-19 00:00:00

abstract：:Pharmacokinetic and metabolic studies with 3H-etilefrine were performed to assess the importance of a first-pass effect on the pharmacodynamic action of this sympathomimetic amine. Identical amounts of 3H-activity, ca. 80% of the dose, were excreted in the urine after intravenous or oral administration, which indicate...

journal_title：European journal of clinical pharmacology

authors： Hengstmann JH,Weyand U,Dengler HJ

更新日期：1975-12-19 00:00:00

abstract：:The effects of intravenous strophanthin K (0.125 and 0.25 MG) and lanatoside C (0.4, 0.8 and 1.6 mg) on systolic time intervals (STI) and impedance plethysmographic (IP)P values were studied in ten patients with compensated coronary heart disease. The heart rate decreased significantly during a two-hour study in the l...

journal_title：European journal of clinical pharmacology

authors： Matos L,Békés M,Polák G,Rausch J,Török E

更新日期：1975-10-10 00:00:00

abstract：:The cardiovascular and respiratory actions of the adrenergic beta adrenoceptive drug sotalol have been studied in an open, short term trial. Fifteen patients with angina performed standardized orthostatic and exercise tests before and after injection of 20 mg sotalol intravenously. Although there was a significant red...

journal_title：European journal of clinical pharmacology

authors： Areskog NH,Cullhed I,Ringqvist I,Ström G

更新日期：1975-08-14 00:00:00

abstract：:Verapamil, 0.1 mg/kg body wt, was injected i.v. over 2 minutes in 8 subjectively healthy middle-aged men, followed by a continuous infusion of 0.007 mg/kg body wt per minute. Prior to the injection several of the subjects had raised pulmonary or systemic arterial pressures. At rest, the central pressures increased sli...

journal_title：European journal of clinical pharmacology

authors： Atterhög JH,Ekelund LG

更新日期：1975-06-13 00:00:00

abstract：:Clonazepam (CNP) and its principal metabolite in plasma, 7-amino-CNP (ACNP), have been investigated in a prospective study of 27 newly diagnosed epileptics and correlated with specified side-effects. At a daily dose of 6 mg, the average plasma levels of both substances were about 50ng/ml, and individual values ranged ...

journal_title：European journal of clinical pharmacology

authors： Sjö O,Hvidberg EF,Naestoft J,Lund M

更新日期：1975-04-04 00:00:00

abstract：:The effect of a new dopamine receptor stimulating agent, piribedil (ET 495), was studied in 10 patients with Parkinson's syndrome, who had had no or a poor response to previous L-DOPA treatment, or had displayed marked side effects during L-DOPA administration. Piribedil produced significant improvement of the functio...

journal_title：European journal of clinical pharmacology

authors： Engel J,Granerus AK,Svanborg A

更新日期：1975-04-04 00:00:00

abstract：:It was considered that double-blind crossover studies of therapeutic efficacy after acute injury could well be done in patients who required surgical removal of impacted wisdom teeth from both sides of the lower jaw. In the present trial 24 healthy patients received either placebo or ibuprofen (Brufen: 400 mg three ti...

journal_title：European journal of clinical pharmacology

authors： Lökken P,Olsen I,Bruaset I,Norman-Pedersen K

更新日期：1975-04-04 00:00:00

abstract：:General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readil...

journal_title：European journal of clinical pharmacology

authors： Vaughan DP,Mallard DJ,Trainor A,Mitchard M

更新日期：1975-02-28 00:00:00

abstract：:Four subjects received 5 mg 14C-glipizide orally, 3 subjects 1 mg intravenously and 2 subjects 5 mg 14C-glibenclamide orally. Plasma levels of radioactivity, and urinary and faecal excretion were measured. For both drugs the disappearance of radioactivity from plasma followed complex kinetics and the apparent half-liv...

journal_title：European journal of clinical pharmacology

authors： Balant L,Fabre J,Zahnd GR

更新日期：1975-01-01 00:00:00